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CBD and Gut Health: Can It Aid Digestive Wellness?

 CBD and Gut Health

Our guts contain roughly 10 trillion microbes. These tiny inhabitants play a crucial role in our digestive system, aiding nutrient absorption, immune function and mood regulation.

In essence, our guts are bustling metropolises of microbial life, quietly working in harmony to support our overall health and well-being.

CBD, a hemp-based cannabinoid, may help to support this community, with the potential to balance the gut microbiota to promote a healthy gut and alleviate digestive issues.

Let’s explore more about the CBD-gut health connection below.

Getting To Know Your Gut

Your digestive system consists of a tract that allows you to consume food and eliminate waste. It includes the mouth, esophagus, stomach, small intestine, large intestine and anus. Microbes in the gut help to digest and break down food to deliver energizing nutrients to the body. These microbes team up with components of the nervous system (nerves), blood and hormones to complete the process.

Within the gut are also immune cells. In fact, 70 to 80% of immune cells are found in the digestive tract, and they also interact intimately with the microbiome.

Traditionally, it was understood that the gut microbiome played a role in local immune responses within the gut, helping to maintain balance between beneficial and harmful gut microbiota and preventing sickness or inflammation.

However, recent research has revealed that the influence of the gut microbiome extends beyond the gut itself and can impact systemic immunity, meaning overall immune system function throughout the body.

The CBD-Gut Health Connection

CBD, a natural component of the Cannabis sativa plant, may contain specific properties and mechanisms that can help to support overall health, including gut function. This is largely due to its function within the endocannabinoid system, a complex network of receptors and molecules found throughout the body, including the gastrointestinal tract.

This system consists of the following:

  • Endocannabinoids – These naturally occurring cannabinoids are neurotransmitters that the body synthesizes to regulate such functions as mood, appetite, feeling and immune response.
  • Cannabinoid receptors – To complete their task, endocannabinoids must bind with one of two types of cannabinoid receptors. The first, CB1 receptors, are found in the central nervous system, which includes the brain and spinal cord. The second, CB2 receptors, are primarily found in immune cells, peripheral tissues and organs, particularly those involved in the immune system. As such, they help to regulate various immune responses.
  • Enzymes – After endocannabinoids trigger the correct response, enzymes work to break it down and return balance to the body.

CBD within the body works very similarly to endocannabinoids. While their role is not yet fully understood by researchers, it’s believed that CBD can interact with both CB1 and CB2 receptors to initiate processes within the gut and beyond that help regulate:

  • Physical sensations
  • Immune responses
  • Mood
  • Appetite
  • Sleep
  • Memory
  • Reproduction and fertility

CBD Benefits For Gut Health

While research on CBD oil benefits is still ongoing, there are several ways in which CBD might contribute to maintaining proper digestive health.

#1 CBD May RegulateGut Inflammation

One potential benefit of CBD is its ability to reduce inflammation. Some studies suggest that CBD may have anti-inflammatory properties, which could theoretically help to calm inflammation within the digestive tract.

However, it's important to note that research in this area is still in its early stages, and more studies are needed to fully understand CBD's effects on gut inflammation.

#2 CBD May Support Gut Motility

CBD may also play a role in regulating gut motility, or the movement of food through the digestive system. By interacting with cannabinoid receptors in the gut and nervous system, CBD could potentially influence the speed and efficiency of digestion.

#3 CBD May Help to Maintain Healthy Gut Microbiome

The endocannabinoid system plays a crucial role in regulating various physiological processes, including immune function and inflammation, both of which can impact the composition of the gut microbiome.

That said, some studies do suggest that CBD may have anti-inflammatory and antioxidative properties that could support a healthy gut microbiome.

#4 CBD May Help to Maintain the Gut Barrier

CBD might also help protect the integrity of the gut barrier, which is essential for preventing harmful substances from leaking into the bloodstream. Conversely, when this barrier is compromised, a condition known as leaky gut occurs, allowing toxins and pathogens to escape the gut and potentially trigger systemic inflammation.

How to Choose the Right CBD For You

When it comes to choosing the best CBD oil product to promote digestive health, there are several factors to consider to ensure you're getting a high-quality and effective product.

Firstly, consider the forms and types of CBD that suit your needs and preferences. CBD is available in various forms, including:

  • Oils
  • Capsules
  • Edibles
  • Topicals
  • Vape products

Each delivery method offers unique advantages and disadvantages, so choose one that aligns with your lifestyle and desired effects. For example, you’ll likely feel the effect of CBD oils faster than CBD edibles. However, CBD edibles may stay in your body longer, prolonging their effects.

Next, look for CBD products that are sourced from reputable manufacturers and undergo third-party testing for potency and purity. To verify this, a company will provide a Certificate of Analysis. This certificate ensures that the product contains the advertised amount of CBD and is free from harmful contaminants such as pesticides, heavy metals and residual solvents. Also, avoid products with unnecessary additives or fillers.

Lastly, consider the concentration of CBD in the product. CBD products vary in potency, so it's essential to select a concentration that matches your individual needs and desired effects. Beginners may opt for lower concentrations, while those with more experience or specific health concerns may prefer higher concentrations.

Make the Right Choice For Your Gut Health With Zebra CBD

Overall, CBD may help to support the health of your gut microbiome and regulate harmful immune responses.

If you’re looking for a CBD you can trust, look no further than Zebra CBD. We provide CBD oils and CBD gummies for sale, as well as CBD chewable tablets and CBD topicals to meet every preference.

Our CBD products are also made with high-quality premium hemp, so you know that you’re delivering nothing but goodness to your gut microbiome.

Hungry for CBD? Shop Zebra CBD today.




  1. The Ohio State University. Everything you need to know about gut health.
  2. Cleveland Clinic. Digestive System.
  3. Harvard Health Publishing. The endocannabinoid system: Essential and mysterious.
  4. Nature. Supporting gut health with medicinal cannabis in people with advanced: potential benefits and challenges.
  5. ScienceDirect. Cannabidiol and Intestinal Motility: a Systematic Review.

Co-founder of Copycat Copywriters, Adam has written for dozens of CBD and cannabis companies on a wide array of topics, including regulations, economics, farming practices and biochemistry.

About the Author

Adam Biederman Image

Adam Biederman

As co-founder and lead writer of Copycat Copywriters, one of Adam’s primary areas of expertise is within the budding CBD and cannabis space. He has written for dozens of CBD and cannabis companies, producing a collection of white papers, press releases, blog posts, articles and ebooks about a wide array of industry-related subjects, including regulations, economics, farming practices and biochemistry.

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